Reversible cardiac valvular disease in catastrophic antiphospholipid syndrome.

Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome

Libman-Sacks endocarditis is characterized by sterile and verrucous lesions that predominantly affect the aortic and mitral valves. In most cases, patients do not have significant valvular dysfunction. However, patients with significant valvular dysfunction may present with serious complications such as cardiac failure, arrhythmias, and thromboembolic events. Recently, association of Libman-Sac...

The Flare Up of Catastrophic Antiphospholipid Syndrome: a Report of an Immunosuppressive Withdrawal-Induced Case

Antiphospholipid syndrome (APS) is a systemic disease that causes venous and arterial thrombosis in virtually any organ. Sometimes it is complicated into pulmonary infarction and cavitation, pulmonary hypertension, and catastrophic course with high morbidity and mortality. The present case is a 35-year-old woman with one episode of postpartum deep veins throm-bosis (DVT) 12 years earlier and th...

Classification criteria for antiphospholipid syndrome: the case for cardiac valvular disease.

The cardiac manifestations of antiphospholipid syndrome and their echocardiographic recognition.

Antiphospholipid syndrome is an autoimmune disorder characterized by the presence of antiphospholipid antibodies, hypercoagulability, vascular thrombosis, and recurrent fetal loss. Cardiac involvement occurs frequently. Leaflet thickening and vegetations are detected quite often echocardiographically, but hemodynamically significant stenotic and/or regurgitant valvular disease is uncommon. Anti...

Catastrophic antiphospholipid syndrome (CAPS) precipitated by cardiac surgery: A case report and review of the literature

Background: A devastating complication of antiphospholipid syndrome (APS) is catastrophic antiphospholipid syndrome (CAPS), which is extremely rare, difficult to diagnose, and portends a poor prognosis with high mortality. Intra-abdominal and obstetric surgeries have been regarded as precipitating factors in the development of CAPS in patients with pre-existing APS. We present the unique case o...